Dr. Breanne Holmes
Tasks at the Ecotox Centre
- Derivation of environmental quality criteria for surface waters for BAFU
- Derivation of ad hoc soil guidance values
Areas of Expertise
- Endocrine disruption
- Aquatic ecotoxicology and risk assessment
- Development of new approach methodologies (iPSC-derived organoids, MALDI MSI, embryo tests)
- Analytical and bioanalytical chemistry
CV
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since 2024
Scientist in risk assessment at the Ecotox Centre
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2022 - 2024
Specialist in Biodetection: Nestlé (Lausanne, Switzerland)
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2019 - 2022
Scientific Manager, Ecotoxicology Expert: Bayer (Monheim am Rhein, Germany)
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2017 - 2019
Postdoc: Orebro Universitet (Orebro, Sweden)
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2016
Teaching Fellow: Eberhard Karls Universität Tübingen (Germany)
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2012 - 2017
PhD in Environmental Sciences and Engineering: Gillings School of Global Public Health at the University of North Carolina, Chapel Hill (USA)
Dissertation: Occurrence and Control of Estrogenic and Androgenic Activity in Water -
2011 - 2012
Teacher (Hanoi, Vietnam)
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2009 - 2011
Master of Science in Chemistry: University of Massachusetts, Amherst (USA)
MS Thesis: Selective Inhibition Studies of Factor Inhibiting HIF (FIH) -
2004 - 2008
Bachelor of Science in Chemistry: University of Rochester (USA)
BS Thesis: The Synthesis of HT Cytochrome c Mutants and Their Effect on the Redox Potential of the Heme
Publications
Burden, N.; Brown, R.J.; Holmes, B.; Panter, G.H.; Salinas, E.R.; Sewell, F.; Weltje, L.; Wheeler, J.R.; Wolf, Y.; Lagadic, L., 2023. An international cross-laboratory survey on fish vitellogenin analysis: Methodological challenges and opportunities for best practice. Regulatory Toxicology and Pharmacology. 145, DOI: 10.1016/j.yrtph.2023.105501
Holmes, B.E., Smeester, L., Fry, R.C., Weinberg, H.S., 2019. Disinfection Byproducts Bind Human Estrogen Receptor-α. Environmental Toxicology and Chemistry, 38(5), pp. 956–964, DOI: 10.1002/etc.4377
Holmes, B.E., Smeester, L., Fry, R.C., Weinberg, H.S., 2017. Identification of endocrine active disinfection by-products (DBPs) that bind to the androgen receptor. Chemosphere, 187, pp. 114–122, DOI: 10.1016/j.chemosphere.2017.08.105
Flagg, S.C., Martin, C.B., Taabazuing, C.Y., Holmes, B.E., Knapp, M.J., 2012. Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH). Journal of Inorganic Biochemistry, 113, pp. 25–30, DOI: 10.1016/j.jinorgbio.2012.03.002
Saban, E.; Chen, Y.-H.; Hangasky, J.A.; Taabazuing, C.Y.; Holmes, B.E.; Knapp, M.J., 2011. The second coordination sphere of FIH controls hydroxylation. Biochemistry, 50(21), pp. 4733–4740, DOI: 10.1021/bi102042t