Dr. Breanne Holmes

Dr. Breanne Holmes

Contact

Send mailTel. +41 58 765 5206
LinkedIn

Centre Ecotox
GR B0 391
EPFL ENAC IIE-GE
Station 2
1015 Lausanne

Tasks at the Ecotox Centre

  • Derivation of environmental quality criteria for surface waters for BAFU
  • Derivation of ad hoc soil guidance values

 

Areas of Expertise

  • Endocrine disruption
  • Aquatic ecotoxicology and risk assessment
  • Development of new approach methodologies (iPSC-derived organoids, MALDI MSI, embryo tests)
  • Analytical and bioanalytical chemistry

CV

  • since 2024

    Scientist in risk assessment at the Ecotox Centre

  • 2022 - 2024

    Specialist in Biodetection: Nestlé (Lausanne, Switzerland)

  • 2019 - 2022

    Scientific Manager, Ecotoxicology Expert: Bayer (Monheim am Rhein, Germany)

  • 2017 - 2019

    Postdoc: Orebro Universitet (Orebro, Sweden)

  • 2016

    Teaching Fellow: Eberhard Karls Universität Tübingen (Germany)

  • 2012 - 2017

    PhD in Environmental Sciences and Engineering: Gillings School of Global Public Health at the University of North Carolina, Chapel Hill (USA)
    Dissertation: Occurrence and Control of Estrogenic and Androgenic Activity in Water

  • 2011 - 2012

    Teacher (Hanoi, Vietnam)

  • 2009 - 2011

    Master of Science in Chemistry: University of Massachusetts, Amherst (USA)
    MS Thesis: Selective Inhibition Studies of Factor Inhibiting HIF (FIH)

  • 2004 - 2008

    Bachelor of Science in Chemistry: University of Rochester (USA)
    BS Thesis: The Synthesis of HT Cytochrome c Mutants and Their Effect on the Redox Potential of the Heme

Publications

Burden, N.; Brown, R.J.; Holmes, B.; Panter, G.H.; Salinas, E.R.; Sewell, F.; Weltje, L.; Wheeler, J.R.; Wolf, Y.; Lagadic, L., 2023. An international cross-laboratory survey on fish vitellogenin analysis: Methodological challenges and opportunities for best practice.  Regulatory Toxicology and Pharmacology. 145, DOI: 10.1016/j.yrtph.2023.105501

Holmes, B.E., Smeester, L., Fry, R.C., Weinberg, H.S., 2019. Disinfection Byproducts Bind Human Estrogen Receptor-α.  Environmental Toxicology and Chemistry, 38(5), pp. 956–964, DOI: 10.1002/etc.4377

Holmes, B.E., Smeester, L., Fry, R.C., Weinberg, H.S., 2017. Identification of endocrine active disinfection by-products (DBPs) that bind to the androgen receptor. Chemosphere, 187, pp. 114–122, DOI: 10.1016/j.chemosphere.2017.08.105

Flagg, S.C., Martin, C.B., Taabazuing, C.Y., Holmes, B.E., Knapp, M.J., 2012. Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH). Journal of Inorganic Biochemistry, 113, pp. 25–30, DOI: 10.1016/j.jinorgbio.2012.03.002

Saban, E.; Chen, Y.-H.; Hangasky, J.A.; Taabazuing, C.Y.; Holmes, B.E.; Knapp, M.J., 2011. The second coordination sphere of FIH controls hydroxylation. Biochemistry, 50(21), pp. 4733–4740, DOI: 10.1021/bi102042t